The aim of this study was to assess the nurse's awareness regarding hemodialysis complications. Subjects and Methods: A descriptive research design was utilized to conduct this study. This study was carried out at the hemodialysis unit in Manfalut central Hospital, Manfalut city - Assiut.The study sample consisted of nurses 35 nurses; ( males and females) working in the hemodialysis unit at Manfalut central Hospital, age ranges between 18 - 55 years and agreed to participate in the study. Self-administered questionnaire sheet was utilized to collect data pertinent to the study with the following parts; Part 1: ''Nurse's sociodemographic characteristics'', Part 2: ''Nurse's awareness regarding hemodialysis practices'', Part 3: ''Nurse's awareness regarding hemodialysis complications''. Results: (88.6%) of the studied nurses were having good level of knowledge regarding hemodialysis complications and (11.4%) of them were having poor knowledge level. Most of the studied nurses were females and their age ranged from (18-27) years. Conclusion: There was a highly statistically significant difference between nurse's knowledge regarding hemodialysis complications with their years of experience. Recommendations: Increase awareness of nurses through attending scientific meetings and conferences is important to keep the nurses pace with the rapidly growing wealth of knowledge and practice regarding hemodialysis for preventing its complications.